PERSPECTIVES
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2295-2314
Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-
Robert C. Newton and
Carl P. Decicco
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2315-2317
High-Throughput Nuclear Magnetic Resonance-Based Screening
Philip J. Hajduk,
Tobias Gerfin,
Jean-Marc Boehlen,
Markus Häberli,
Daniel Marek, and
Stephen W. Fesik
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ARTICLES
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2318-2331
Nonapeptide Analogues Containing (R)-3-Hydroxybutanoate and -Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein
Sorana Poenaru,
José R. Lamas,
Gerd Folkers,
José A. López de Castro,
Dieter Seebach, and
Didier Rognan
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2332-2343
Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent
Venkatram R. Atigadda,
Wayne J. Brouillette,
Franco Duarte,
Shoukath M. Ali,
Yarlagadda S. Babu,
Shanta Bantia,
Pooran Chand,
Naiming Chu,
John A. Montgomery,
David A. Walsh,
Elise A. Sudbeck,
James Finley,
Ming Luo,
Gillian M. Air, and
Graeme W. Laver
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2344-2350
Molecular Modeling and Synthesis of Inhibitors of Herpes Simplex Virus Type 1 Uracil-DNA Glycosylase
Hongmao Sun,
Chengxin Zhi,
George E. Wright,
Daniela Ubiali,
Massimo Pregnolato,
Annalisa Verri,
Federico Focher, and
Silvio Spadari
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2351-2357
Pharmacophore Development for Corticotropin-Releasing Hormone: New Insights into Inhibitor Activity
Paul A. Keller,
Maria Bowman,
Kor Hin Dang,
James Garner,
Scott P. Leach,
Roger Smith, and
Adam McCluskey
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2358-2363
Structure-Based Design, Synthesis, and X-ray Crystallography of a High-Affinity Antagonist of the Grb2-SH2 Domain Containing an Asparagine Mimetic
Pascal Furet,
Carlos García-Echeverría,
Brigitte Gay,
Joseph Schoepfer,
Martin Zeller, and
Joseph Rahuel
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2364-2372
Solution Structure of -Conotoxin ImI by 1H Nuclear Magnetic Resonance
John Gehrmann,
Norelle L. Daly,
Paul F. Alewood, and
David J. Craik
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2373-2382
Structure-Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor
Brian D. Palmer,
Alan J. Kraker,
Brian G. Hartl,
Athanasia D. Panopoulos,
Robert L. Panek,
Brian L. Batley,
Gina H. Lu,
Susanne Trumpp-Kallmeyer,
H. D. Hollis Showalter, and
William A. Denny
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2383-2393
Structure-Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents
Swarna A. Gamage,
Julie A. Spicer,
Graham J. Atwell,
Graeme J. Finlay,
Bruce C. Baguley, and
William A. Denny
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2394-2402
Apstatin Analogue Inhibitors of Aminopeptidase P, a Bradykinin-Degrading Enzyme
Linda L. Maggiora,
Arthur T. Orawski, and
William H. Simmons
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2403-2408
-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines
Philip J. Rybczynski,
Donald W. Combs,
Kimberly Jacobs,
Richard P. Shank, and
Barry Dubinsky
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2409-2421
Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene -Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation
Melissa S. Egbertson,
Jacquelynn J. Cook,
Bohumil Bednar,
John D. Prugh,
Rodney A. Bednar,
Stanley L. Gaul,
Robert J. Gould,
George D. Hartman,
Carl F. Homnick,
Marie A. Holahan,
Laura A. Libby,
Joseph J. Lynch, Jr.,
Robert J. Lynch,
Gary R. Sitko,
Maria T. Stranieri, and
Laura M. Vassallo
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2422-2431
Structure-Activity Relationships for a Class of Inhibitors of Purine Nucleoside Phosphorylase
Victor Farutin,
Lori Masterson,
Adriano D. Andricopulo,
Jianming Cheng,
Brad Riley,
Ryan Hakimi,
Jack W. Frazer, and
Eugene H. Cordes
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2432-2440
Effects of C-4 Stereochemistry and C-4' Hydroxylation on the Iron Clearing Efficiency and Toxicity of Desferrithiocin Analogues
Raymond J. Bergeron,
Jan Wiegand,
James S. McManis,
Bruce H. McCosar,
William R. Weimar,
Gary M. Brittenham, and
Richard E. Smith
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2441-2446
Antitumor Agents. 194. Synthesis and Biological Evaluations of 4--Mono-, -Di-, and -Trisubstituted Aniline-4'-O-demethyl-podophyllotoxin and Related Compounds with Improved Pharmacological Profiles
Xiao-Kang Zhu,
Jian Guan,
Yoko Tachibana,
Kenneth F. Bastow,
Sung Jin Cho,
Huey-Hwa Cheng,
Yung-Chi Cheng,
Marc Gurwith, and
Kuo-Hsiung Lee
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2447-2455
Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase Inhibitors and Antitumor Agents: Synthesis and Biological Activities of 2,4-Diamino-5-methyl-6-[(monosubstituted anilino)methyl]- pyrido[2,3-d]pyrimidines
Aleem Gangjee,
Ona Adair, and
Sherry F. Queener
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2456-2468
Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes
Marvin J. Meyers,
Jun Sun,
Kathryn E. Carlson,
Benita S. Katzenellenbogen, and
John A. Katzenellenbogen
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2469-2477
Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines
Jon L. Wright,
Tracy F. Gregory,
Christopher F. Bigge,
Peter A. Boxer,
Kevin Serpa,
Leonard T. Meltzer, and
Lawrence D. Wise
, Sui Xiong Cai,
Jon E. Hawkinson,
Christopher S. Konkoy,
Edward R. Whittemore,
Richard M. Woodward, and
Zhang-Lin Zhou
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2478-2484
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: Excitatory Amino Acid Antagonists with Combined Glycine/NMDA and AMPA Receptor Affinity
Daniela Catarzi,
Vittoria Colotta,
Flavia Varano,
Lucia Cecchi,
Guido Filacchioni,
Alessandro Galli, and
Chiara Costagli
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2485-2489
Self-Immolative Anthracycline Prodrugs for Suicide Gene Therapy
Ion Niculescu-Duvaz,
Dan Niculescu-Duvaz,
Frank Friedlos,
Robert Spooner,
Janet Martin,
Richard Marais, and
Caroline J. Springer
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2490-2490
Organic Reactions. Volume 53 Leo A. Paquette, Editor-in-Chief. John Wiley & Sons, Inc., New York. 1998. vii + 654 pp. 16 x 24 cm. ISBN 0-471-32609-7. $95.00.
Karen S. Kirschbaum
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2491-2491
Textbook of Organic Medicinal and Pharmaceutical Chemistry. Tenth Edition Edited by Jaime N. Delgado and William A. Remers. Lippincott-Raven, Philadelphia, PA. 1998. xv + 974 pp. 22 × 28.5 cm. ISBN 0-397-51583-9. $69.50.
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ADDITIONS AND CORRECTIONS
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2492-2492
Synthesis and Biological Evaluation of Boron-Containing Polyamines as Potential Agents for Neutron Capture Therapy of Brain Tumors
Jin-Cong Zhuo,
Jianping Cai,
Albert H. Soloway,
Rolf F. Barth,
Dianne M. Adams,
Weihua Ji, and
Werner Tjarks
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