Journal of Medicinal Chemistry
Volume 42, Issue 13 (July 1, 1999)
Copyright © 1999 American Chemical Society

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PERSPECTIVES

2295-2314

Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor- Robert C. Newton and Carl P. Decicco [Full Article - PDF]

2315-2317

High-Throughput Nuclear Magnetic Resonance-Based Screening Philip J. Hajduk, Tobias Gerfin, Jean-Marc Boehlen, Markus Häberli, Daniel Marek, and Stephen W. Fesik [Full Article - PDF]

ARTICLES

2318-2331

Nonapeptide Analogues Containing (R)-3-Hydroxybutanoate and -Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein Sorana Poenaru, José R. Lamas, Gerd Folkers, José A. López de Castro, Dieter Seebach, and Didier Rognan [Full Article - PDF]

2332-2343

Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent Venkatram R. Atigadda, Wayne J. Brouillette, Franco Duarte, Shoukath M. Ali, Yarlagadda S. Babu, Shanta Bantia, Pooran Chand, Naiming Chu, John A. Montgomery, David A. Walsh, Elise A. Sudbeck, James Finley, Ming Luo, Gillian M. Air, and Graeme W. Laver [Full Article - PDF]

2344-2350

Molecular Modeling and Synthesis of Inhibitors of Herpes Simplex Virus Type 1 Uracil-DNA Glycosylase Hongmao Sun, Chengxin Zhi, George E. Wright, Daniela Ubiali, Massimo Pregnolato, Annalisa Verri, Federico Focher, and Silvio Spadari [Full Article - PDF]

2351-2357

Pharmacophore Development for Corticotropin-Releasing Hormone: New Insights into Inhibitor Activity Paul A. Keller, Maria Bowman, Kor Hin Dang, James Garner, Scott P. Leach, Roger Smith, and Adam McCluskey [Full Article - PDF]

2358-2363

Structure-Based Design, Synthesis, and X-ray Crystallography of a High-Affinity Antagonist of the Grb2-SH2 Domain Containing an Asparagine Mimetic Pascal Furet, Carlos García-Echeverría, Brigitte Gay, Joseph Schoepfer, Martin Zeller, and Joseph Rahuel [Full Article - PDF]

2364-2372

Solution Structure of -Conotoxin ImI by 1H Nuclear Magnetic Resonance John Gehrmann, Norelle L. Daly, Paul F. Alewood, and David J. Craik [Full Article - PDF]

2373-2382

Structure-Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor Brian D. Palmer, Alan J. Kraker, Brian G. Hartl, Athanasia D. Panopoulos, Robert L. Panek, Brian L. Batley, Gina H. Lu, Susanne Trumpp-Kallmeyer, H. D. Hollis Showalter, and William A. Denny [Full Article - PDF]

2383-2393

Structure-Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents Swarna A. Gamage, Julie A. Spicer, Graham J. Atwell, Graeme J. Finlay, Bruce C. Baguley, and William A. Denny [Full Article - PDF]

2394-2402

Apstatin Analogue Inhibitors of Aminopeptidase P, a Bradykinin-Degrading Enzyme Linda L. Maggiora, Arthur T. Orawski, and William H. Simmons [Full Article - PDF]

2403-2408

-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines Philip J. Rybczynski, Donald W. Combs, Kimberly Jacobs, Richard P. Shank, and Barry Dubinsky [Full Article - PDF]

2409-2421

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene -Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation Melissa S. Egbertson, Jacquelynn J. Cook, Bohumil Bednar, John D. Prugh, Rodney A. Bednar, Stanley L. Gaul, Robert J. Gould, George D. Hartman, Carl F. Homnick, Marie A. Holahan, Laura A. Libby, Joseph J. Lynch, Jr., Robert J. Lynch, Gary R. Sitko, Maria T. Stranieri, and Laura M. Vassallo [Full Article - PDF]

2422-2431

Structure-Activity Relationships for a Class of Inhibitors of Purine Nucleoside Phosphorylase Victor Farutin, Lori Masterson, Adriano D. Andricopulo, Jianming Cheng, Brad Riley, Ryan Hakimi, Jack W. Frazer, and Eugene H. Cordes [Full Article - PDF]

2432-2440

Effects of C-4 Stereochemistry and C-4' Hydroxylation on the Iron Clearing Efficiency and Toxicity of Desferrithiocin Analogues Raymond J. Bergeron, Jan Wiegand, James S. McManis, Bruce H. McCosar, William R. Weimar, Gary M. Brittenham, and Richard E. Smith [Full Article - PDF]

2441-2446

Antitumor Agents. 194. Synthesis and Biological Evaluations of 4--Mono-, -Di-, and -Trisubstituted Aniline-4'-O-demethyl-podophyllotoxin and Related Compounds with Improved Pharmacological Profiles Xiao-Kang Zhu, Jian Guan, Yoko Tachibana, Kenneth F. Bastow, Sung Jin Cho, Huey-Hwa Cheng, Yung-Chi Cheng, Marc Gurwith, and Kuo-Hsiung Lee [Full Article - PDF]

2447-2455

Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase Inhibitors and Antitumor Agents: Synthesis and Biological Activities of 2,4-Diamino-5-methyl-6-[(monosubstituted anilino)methyl]- pyrido[2,3-d]pyrimidines Aleem Gangjee, Ona Adair, and Sherry F. Queener [Full Article - PDF]

2456-2468

Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes Marvin J. Meyers, Jun Sun, Kathryn E. Carlson, Benita S. Katzenellenbogen, and John A. Katzenellenbogen [Full Article - PDF]

2469-2477

Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines Jon L. Wright, Tracy F. Gregory, Christopher F. Bigge, Peter A. Boxer, Kevin Serpa, Leonard T. Meltzer, and Lawrence D. Wise , Sui Xiong Cai, Jon E. Hawkinson, Christopher S. Konkoy, Edward R. Whittemore, Richard M. Woodward, and Zhang-Lin Zhou [Full Article - PDF]

2478-2484

4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: Excitatory Amino Acid Antagonists with Combined Glycine/NMDA and AMPA Receptor Affinity Daniela Catarzi, Vittoria Colotta, Flavia Varano, Lucia Cecchi, Guido Filacchioni, Alessandro Galli, and Chiara Costagli [Full Article - PDF]

2485-2489

Self-Immolative Anthracycline Prodrugs for Suicide Gene Therapy Ion Niculescu-Duvaz, Dan Niculescu-Duvaz, Frank Friedlos, Robert Spooner, Janet Martin, Richard Marais, and Caroline J. Springer [Full Article - PDF]

2490-2490

Organic Reactions. Volume 53 Leo A. Paquette, Editor-in-Chief. John Wiley & Sons, Inc., New York. 1998. vii + 654 pp. 16 x 24 cm. ISBN 0-471-32609-7. $95.00. Karen S. Kirschbaum [Full Article - PDF]

2491-2491

Textbook of Organic Medicinal and Pharmaceutical Chemistry. Tenth Edition Edited by Jaime N. Delgado and William A. Remers. Lippincott-Raven, Philadelphia, PA. 1998. xv + 974 pp. 22 × 28.5 cm. ISBN 0-397-51583-9. $69.50. [Full Article - PDF]

ADDITIONS AND CORRECTIONS

2492-2492

Synthesis and Biological Evaluation of Boron-Containing Polyamines as Potential Agents for Neutron Capture Therapy of Brain Tumors Jin-Cong Zhuo, Jianping Cai, Albert H. Soloway, Rolf F. Barth, Dianne M. Adams, Weihua Ji, and Werner Tjarks [Full Article - PDF]